Ulrich Klar Selected Research

sagopilone

4/2011	Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells.
1/2011	Evaluation of activity and combination strategies with the microtubule-targeting drug sagopilone in breast cancer cell lines.
3/2010	Comparative profiling of the novel epothilone, sagopilone, in xenografts derived from primary non-small cell lung cancer.
6/2009	Sagopilone inhibits breast cancer bone metastasis and bone destruction due to simultaneous inhibition of both tumor growth and bone resorption.
4/2009	Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases.
7/2008	Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone.

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Ulrich Klar Research Topics

Disease

9	Neoplasms (Cancer) 01/2020 - 07/2008
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2011 - 04/2009
3	Breast Neoplasms (Breast Cancer) 01/2011 - 04/2009
2	Aneuploidy (Aneuploid) 01/2020 - 04/2011
2	Neoplasm Metastasis (Metastasis) 06/2009 - 04/2009
1	Leiomyoma (Uterine Fibroids) 11/2018
1	Endometriosis 11/2018
1	Polyploidy 01/2011
1	Paraplegia (Spastic Paraplegia) 06/2009
1	Cachexia 06/2009
1	Bone Resorption 06/2009
1	Melanoma (Melanoma, Malignant) 04/2009
1	Brain Neoplasms (Brain Tumor) 04/2009
1	Glioblastoma (Glioblastoma Multiforme) 04/2009
1	Carcinoma (Carcinomatosis) 07/2008

Drug/Important Bio-Agent (IBA)

6	Epothilones (Epothilone)IBA 04/2011 - 07/2008
6	sagopiloneIBA 04/2011 - 07/2008
4	Paclitaxel (Taxol)FDA LinkGeneric 04/2011 - 07/2008
2	TubulinIBA 03/2010 - 07/2008
1	Phosphotransferases (Kinase)IBA 01/2020
1	Progesterone FDA LinkGeneric 11/2018
1	Antimitotic AgentsIBA 01/2016
1	NocodazoleIBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 01/2011
1	Small Interfering RNA (siRNA)IBA 01/2011
1	Pharmaceutical PreparationsIBA 01/2011
1	Excipients (Suspending Agents)IBA 01/2011
1	Protein Isoforms (Isoforms)IBA 03/2010
1	Antineoplastic Agents (Antineoplastics)IBA 04/2009
1	Temozolomide (Temodar)FDA LinkGeneric 04/2009
1	BombesinIBA 09/2008
1	SiliconIBA 09/2008
1	Bombesin Receptors (Bombesin Receptor)IBA 09/2008

Therapy/Procedure

2	Therapeutics 01/2016 - 03/2010